Velocity/Force-pCa Relation

February 22, 2008

Calcium sensitivity (pCa50): negative log of the calcium concentration at half-maximal velocity / force) of thin filament;

Cooperativity (Hill Coefficient): Values are expressed as least-square regression of the fit to the Hill equation ± SE;

Maximal activation (Vmax or Fmax): maximal calcium-activated velocity / of thin filament.

VanBuren, P., et al., Cardiac troponin T isoforms demonstrate similar effects on mechanical performance in a regulated contractile system. Am J Physiol Heart Circ Physiol, 2002. 282(5): p. H1665-71